A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: a proof of concept

Authors Karin Gehring, Martijn M. Stuiver, Eva Visser, Corelien Kloek, Martin van den Bent, Monique Hanse, Cees Tijssen, Geert-Jan Rutten, Martin J.B. Taphoorn, N.K. Aaronson, Margriet Sitskoorn
Published in Neuro-oncology
Publication date 2020
Research groups Innovation of Movement Care
Type Article


Abstract Background: Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs). Methods: Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20-45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months. Results: The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health-related quality of life. Conclusions: This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.

On this publication contributed

  • Corelien Kloek | Researcher | Research group Innovation of Movement Care
    Corelien Kloek
    • Researcher
    • Research group: Innovation of Movement Care

Language English
Published in Neuro-oncology
Year and volume 2020 1
Key words brain neoplasms, cognitive function, exercise, glioma, patient reported outcome measures
Digital Object Identifier 10.1093/neuonc/noz178
Page range 103-115

Innovation of Movement Care