Considering new methodologies in strategies for safety assessment of foods and food ingredients

Authors Brett Jeffery, Gareth Edwards, Alan R. Boobis, Anne Constable, Bobbie Bradford, Jossie A. Garthoff, Cyrille Krul, Bas J. Blaauboer, Jeroen Schuermansk, Mardas Daneshian, Andrew Cockburn
Published in Food and Chemical Toxicology
Publication date 3 March 2016
Research groups Innovative Testing in Life Sciences and Chemistry
Type Article


from the article Abstract Toxicology and safety assessment are changing and require new strategies for evaluating risk that are less depending on apical toxicity endpoints in animal models and relying more on knowledge of the mechanism of toxicity. This manuscript describes a number of developments that could contribute to this change and implement this in a stepwise roadmap that can be applied for the evaluation of food and food ingredients. The roadmap was evaluated in four case studies by using literature and existing data. This preliminary evaluation was shown to be useful. However, this experience should be extended by including examples where experimental work needs to be included. To further implement these new insights in toxicology and safety assessment for the area of food and food ingredients, the recommendation is that stakeholders take action in addressing gaps in our knowledge, e.g. with regard to the applicability of the roadmap for mixtures and food matrices. Further development of the threshold of toxicological concern is needed, as well as cooperation with other sectors where similar schemes are under development. Moreover, a more comprehensive evaluation of the roadmap, also including the identification of the need for in vitro experimental work is recommended.

On this publication contributed

  • Cyrille Krul
    Cyrille Krul
    • Professor
    • Research group: Innovative Testing in Life Sciences and Chemistry

Language English
Published in Food and Chemical Toxicology
Key words Food safety, Integrated assessment strategies, In vitro methodologies, In silico methods
Page range 19-35

Innovative Testing in Life Sciences and Chemistry