Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

Authors Leon Knippels, Katrine Lindholm Bøgh, Iván López‑Expósito, Robert Głogowski, Grégory Bouchaud, Marie Bodinier, Mario Noti, Joost Smit, Ian Kimber, Michelle M. Epstein, Carine Blanchard, Karine Adel‑Patient, Raymond Pieters, Liam O’Mahony, Unni Cecilie Nygaard, Jolanda van Bilsen, Kitty Verhoeckx, Eva Untersmayr, Nicole de Wit, Shanna Bastiaan‑Net
Published in Clinical And Translational Allergy
Publication date 16 June 2016
Research groups Innovative Testing in Life Sciences and Chemistry
Type Article


From the article: Abstract Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing the allergenic potential of novel food proteins. There is no doubt that robust and reliable animal models for the identification and characterization of food allergens would be valuable tools for safety assessment. However, although various animal models have been proposed for this purpose, to date, none have been formally validated as predictive and none are currently suitable to test the allergenic potential of new foods. Here, the design of various animal models are reviewed, including among others considerations of species and strain, diet, route of administration, dose and formulation of the test protein, relevant controls and endpoints measured. DOI: 10.1186/s13601-016-0110-2

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On this publication contributed

  • Raymond Pieters | Professor | Research group Innovative Testing in Life Sciences & Chemistry
    Raymond Pieters
    • Professor
    • Research group: Innovative Testing in Life Sciences and Chemistry

Language English
Published in Clinical And Translational Allergy
Key words Food allergy, Animal models, Novel allergens, Hazard identification

Innovative Testing in Life Sciences and Chemistry