Prognosis of Pain and Physical Functioning in Patients With Knee Osteoarthritis: A systematic review and meta-analysis

Authors Mariëtte de Rooij , Marike van der Leeden , Martijn W. Heymans , Jasmijn Holla , Arja Häkkinen , Willem F. Lems , Leo D. Roorda , Cindy Veenhof , Diana C. Sánchez Ramírez , Henrica de Vet , Joost Dekker
Published in Arthritis Care & Research
Publication date 2016
Research groups Innovation of Movement Care
Type Article

Summary

Objective To systematically summarize the literature on the course of pain in patients with knee osteoarthritis (OA), prognostic factors that predict deterioration of pain, the course of physical functioning, and prognostic factors that predict deterioration of physical functioning in persons with knee OA. Methods A search was conducted in PubMed, CINAHL, Embase, Psych‐INFO, and SPORTDiscus up to January 2014. A meta‐analysis and a qualitative data synthesis were performed. Results Of the 58 studies included, 39 were of high quality. High heterogeneity across studies (I2 >90%) and within study populations (reflected by large SDs of change scores) was found. Therefore, the course of pain and physical functioning was interpreted to be indistinct. We found strong evidence for a number of prognostic factors predicting deterioration in pain (e.g., higher knee pain at baseline, bilateral knee symptoms, and depressive symptoms). We also found strong evidence for a number of prognostic factors predicting deterioration in physical functioning (e.g., worsening in radiographic OA, worsening of knee pain, lower knee extension muscle strength, lower walking speed, and higher comorbidity count). Conclusion Because of high heterogeneity across studies and within study populations, no conclusions can be drawn with regard to the course of pain and physical functioning. These findings support current research efforts to define subgroups or phenotypes within knee OA populations. Strong evidence was found for knee characteristics, clinical factors, and psychosocial factors as prognostics of deterioration of pain and physical functioning.

researchcomponents.publicationcontent.personslist.publicationauthors

  • Cindy Veenhof | Professor | Research group Innovation of Movement Care
    Cindy Veenhof
    • Professor
    • Research groups: Innovation of Movement Care

Language English
Published in Arthritis Care & Research
Year and volume 68 4
Key words osteoartritis
Page range 481-492

Innovation of Movement Care