Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects

Authors Peter T. Theunissen , Bruce Beyer , Sonia Beken
Published in Critical Reviews in Toxicology
Publication date 21 October 2016
Research groups Innovative Testing in Life Sciences and Chemistry
Type Article

Summary

And co-authors William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc de Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matthew Martin, Mary Ellen McNerney, Christine L. Siezen, Dinesh J. Stanislaus, Jane Stewart, Kary E. Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F. Weinbauer, Sandra Wood & Aldert H. Piersma

Language English
Published in Critical Reviews in Toxicology
ISBN/ISSN URN:ISSN:1547-6898
Key words Cross-species evaluation, embryo-fetal developmental toxicity in rat and rabbit, human equivalent dose comparison, pharmaceutical testing, strain differences, systemic dose-based comparison

Innovative Testing in Life Sciences and Chemistry