ONTOX: predicting toxicity with artificial intelligence

Hands holding a test tube
Media.Source: ivarpel.nl

ONTOX aims to deliver a generic strategy for using artificial intelligence (AI) that can be applied to predict toxicity in humans of any chemical at any dose. With the use of big data, novel predictive algorithms will be used to effectively indicate whether a compound of interest provides a risk for human health.

Objective

The vision of the ONTOX consortium is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment.

Results

ONTOX will deliver a generic strategy to create innovative new approach methodologies (NAMs) in order to predict systemic repeated dose toxicity effects. Upon combination with tailored exposure assessment, these will enable human risk assessment. This strategy can be applied to any type of chemical and systemic repeated dose toxicity effect. Application of AI is at the heart of this project.

Impact

ONTOX will have a deep and long-lasting impact on many levels. In particular by consolidating Europe’s world-leading position regarding the development, exploitation, regulation and application of animal-free methods for human risk assessment of chemicals.

Duration

01 May 2021 - 01 May 2026

Approach

Focus will be put on 6 specific new approach methodologies addressing adversities in the liver, kidney and the developing brain induced by a variety of chemicals. Including pharmaceuticals, cosmetics, and food ingredients and biocides.

HU researchers involved in the research

  • Marc Teunis | Researcher | Research group Innovative Testing in Life Sciences and Chemistry
    Marc Teunis
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Cyrille Krul
    Cyrille Krul
    • Professor
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Raymond Pieters | Professor | Research group Innovative Testing in Life Sciences & Chemistry
    Raymond Pieters
    • Professor
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Marie Corradi | Researcher | Lectorate Innovative Testing in Life Sciences and Chemistry
    Marie Corradi
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry

Collaboration with knowledge partners

The project consortium consists of a broad range of European and other research institutes and businesses. For a full overview, please refer to the project's website.

Universiteit Utrecht
Vrije Universiteit Brussel
Maastricht University

Financing

This project has received a grant of 17,211,050 euro under the European Union's Horizon 2020 programme under grant agreement number 963845.

Would you like to collaborate or do you have any questions?

Marc Teunis | Researcher | Research group Innovative Testing in Life Sciences and Chemistry

Marc Teunis

  • Researcher
  • Research group: Innovative Testing in Life Sciences and Chemistry