Virtual Human Platform 4 Safety Assessment

Imagine a world in which we perform precision safety testing of chemicals and pharmaceuticals without using laboratory animals. Imagine that this safety can be assessed for vulnerable groups. Imagine that we know how these substances interact with human biology and physiology and how they can be used safely at home, school or at work.

 

Objective

Assessing the safety of chemicals and pharmaceuticals without using laboratory animals. This is our vision for the future, the vision that underlies the development of the Virtual Human Platform for safety assessment, VHP4Safety.

Results

The Virtual Human Platform will be developed within three interacting research lines (RL):

  • RL1: building the platform
  • RL2: feeding the platform with newly generated data
  • RL3: implementing the platform to ensure stakeholders’ acceptance, governance and sustainability

Duration

01 June 2021 - 31 May 2026

Approach

The VHP integrates data on human physiology, chemical characteristics and perturbations of biological pathways in an inclusive and integrated manner that incorporates:

  • human-relevant scenarios to discriminate vulnerable groups
  • chemicals from different sectors
  • different regulatory and stakeholder needs

HU researchers involved in the research

  • Cyrille Krul
    Cyrille Krul
    • Professor
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Raymond Pieters | Professor | Research group Innovative Testing in Life Sciences & Chemistry
    Raymond Pieters
    • Professor
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Marc Teunis | Researcher | Research group Innovative Testing in Life Sciences and Chemistry
    Marc Teunis
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Alyanne de Haan | Researcher | Lectorate Innovative Testing in Life Sciences and Chemistry
    Alyanne de Haan
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Marie Corradi | Researcher | Lectorate Innovative Testing in Life Sciences and Chemistry
    Marie Corradi
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Jean Paul ten Klooster | Researcher | Research group Innovative Testing in Life Sciences and Chemistry
    Jean Paul ten Klooster
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Mieke Smits | Researcher | Research group Innovative Testing in Life Sciences and Chemistry
    Mieke Smits
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Kitty van Summeren | Researcher | Research group Innovative Testing in Life Sciences & Chemistry
    Kitty van Summeren
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Saertje Verkoeijen
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry

Collaboration with knowledge partners

VHP4Safety – the Virtual Human Platform for safety assessment project NWA 1292.19.272 is part of the NWA research program ‘Research along Routes by Consortia (ORC)’, which is funded by the Netherlands Organization for Scientific Research (NWO). With a budget of over 10 million Euros, the project starts on June 1, 2021 and will last for the duration of 5 years.

Would you like to collaborate or do you have any questions?

Cyrille Krul

Cyrille Krul

  • Professor
  • Research group: Innovative Testing in Life Sciences and Chemistry