Jean Paul ten Klooster PhD, is project leader at the Research Centre for Healthy and Sustainable Living, and at the Research group Innovative Testing in Life Sciences & Chemistry, both at HU University of Applied Sciences Utrecht.
The focus of my research within the research group is the applicability of stem cell-based intestinal organoids. This research looks at: 1) how the growth of these stem cells can be improved, 2) interactions of immune cells with intestinal organoids, 3) mucosal barrier function with regard to the production of mucus and antibacterial proteins.
Much of Jean Paul's research is conducted in collaboration with food and pharma companies, and research institutions such as the WUR, UU and LUMC.
Fields of expertise
- Signal transduction
- Immunological toxicology
- Allergy and intestinal health
- Type 2 diabetes-related proteins derived from an in vitro model of inflamed fat tissue
- N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2
- Docosahexaenoyl Serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signalling in macrophages