N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

Authors YA Wang , P. Plastina , Jean-Paul Vincken , Renate Jansen , Michiel Balvers , Jean Paul ten Klooster , Harry Gruppen , Renger Witkamp , Jocelijn Meijerink
Published in ACS Chemical Neuroscience
Publication date 2017
Research groups Innovative Testing in Life Sciences and Chemistry
Type Article

Summary

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties. Here, we synthesized another amine conjugate of DHA, N-docosahexaenoyl dopamine (DHDA), and tested its immune-modulatory properties in both RAW 264.7 macrophages and BV-2 microglial cells."

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Language English
Published in ACS Chemical Neuroscience
Year and volume 8 3
ISBN/ISSN URN:ISSN:1948-7193
Key words cyclooxygenase-2
Page range 548-557

Innovative Testing in Life Sciences and Chemistry