The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine

Authors Raymond Pieters , Susanne Muckenschnab , Jocelijn Meijerink , Renger F Witkamp , Henk FJ Hendriks , Jean Paul ten Klooster , Nikkie van der Wielen
Published in The Journal of Nutrition
Publication date 26 October 2016
Research groups Innovative Testing in Life Sciences and Chemistry
Type Article

Summary

Abstract from the journal: Glucagon-like peptide 1 (GLP-1) contributes to satiety and plays a pivotal role in insulin secretion and glucose homeostasis. Similar to GLP-1, peptide YY (PYY) and cholecystokinin also influence food intake. The secretion of these hormones by enteroendocrine cells along the intestine is modulated by nutrients. Preparations from the Stevia rebaudiana plant, including rebaudioside A, are increasingly being used as noncaloric sweeteners. doi: 10.3945/​jn.116.232678

researchcomponents.publicationcontent.personslist.publicationauthors

  • Raymond Pieters | Professor | Research group Innovative Testing in Life Sciences & Chemistry
    Raymond Pieters
    • Professor
    • Research groups: Innovative Testing in Life Sciences and Chemistry
  • Jean Paul ten Klooster | Researcher | Research group Innovative Testing in Life Sciences and Chemistry
    Jean Paul ten Klooster
    • Researcher
    • Research groups: Innovative Testing in Life Sciences and Chemistry

Language English
Published in The Journal of Nutrition
Year and volume 146 11
ISBN/ISSN URN:ISSN:0022-3166
Key words glucagon-like peptide 1, GLP-1, peptide YY, gut hormone, ileum, jejunum, duodenum

Raymond Pieters

Raymond Pieters | Professor | Research group Innovative Testing in Life Sciences & Chemistry

Raymond Pieters

  • Professor
  • Research group: Innovative Testing in Life Sciences and Chemistry